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GenProb-PCSM transforms complex germline findings into a single inherited risk score for PCSM and metastatic progression and may facilitate clinical implementation of germline prognostic assessment in PCa.
BCa and inherited genetic susceptibility jointly contribute to increased risk of multiple common diseases, supporting the integration of genetic risk stratification into survivorship care.
An integrated continuum genetic risk model, GenProb-PCa, improves PCa risk stratification beyond binary approaches by capturing heterogeneity in inherited risk and may enable more precise risk-based screening strategies.
Germline PVs in NCCN-recommended DDR genes and the KLK3 I179T variant identify a subset of men at elevated risk of PCSM, including those with apparently localized disease.
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