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This work shows that persistent germinal centers (GCs) support continued affinity maturation of founder clones and ipsilateral boosting preferentially engages these lineages in secondary GCs, and identifies disfavored mutational trajectories within the V3-glycan bnAb lineage, revealing intrinsic constraints on bnAb lin...
Progress is being made in developing vaccine immunogens that induce bnAb B cell lineages in humans and the remaining tasks needed to complete a prototype HIV vaccine are outlined.
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