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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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B. Grüner

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Sep 2026

Abstract A027: Loss of the Y chromosome drives basal identity and metastatic potential via epigenetic reprogramming in pancreatic cancer

Loss of the Y chromosome (LOY) is a common somatic alteration in aging males and many cancer entities, yet its functional role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We sought to determine whether LOY is a recurrent, functionally consequential event in male PDAC and to define its impact on tu...

M. Dorsch, Felix E. G. Beaudry, A. Baginska et al. · 0 citations

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