Design and optimization of HME-based floating dolutegravir extrudates with enhanced drug release and potent anti-viral activity.
The hot-melt extrusion (HME) technique is quite successful in improving the solubility and bioavailability of poorly water-soluble drugs. Herein, we report the development of optimized dolutegravir floating systems prepared by the HME technique using Design-Expert software. Optimized parameters for floating extrudate i...