B. Gisevius

Altered metabolism and endoplasmic reticulum-mitochondria contacts in multiple sclerosis neurons

Background Genetic factors are estimated to account for approximately 30–50% of the risk for developing Multiple sclerosis (MS). Distinct mitochondrial variants, impairments in the respiratory chain, and mitochondrial dysfunction have been reported in individuals affected by MS. Mitochondria and the endoplasmic reticul...