Author

B. Freudenthal

2 papers indexed here

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Aug 2026

Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling.

A non-random nuclear "ribome," the genome-wide landscape of embedded rNMPs, enriched in GC-rich regions, regulatory elements, and telomeres, is revealed, revealing a connection between ribonucleotide processing and transcription-associated DNA topology in human cells.

Deepali L. Kundnani, Yeunsook Lee, Taehwan Yang et al. · Cell · 0 citations

Open access Aug 2026

XRCC1 Enables the Efficient Local Search for DNA Damage by DNA Polymerase Beta

Oxidative DNA damage is a common threat to genomic integrity, arising from endogenous metabolic processes and environmental exposures. If unrepaired, such oxidative DNA damage promotes mutagenesis and genomic instability. Cells counter this through base excision repair (BER), a multi-step pathway requiring the coordina...

Spencer H. Thompson, Kaitlin M. DeHart, M. Schaich et al. · bioRxiv · 0 citations