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B. Edginton-White

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Open access Aug 2026

Dll4 and Jag1a signalling act sequentially and cooperatively to drive hematopoietic stem cell fate specification

Hematopoietic stem and progenitor cells (HSPCs) arise from a specialized subset of arterial endothelial cells, the hemogenic endothelium (HE), during embryonic development and sustain blood production throughout life. Notch signalling is a key regulator of this process: its ligand Jag1 promotes HSPC formation, whereas...

Dashuai Wu, B. Edginton-White, Dorothee Bornhorst et al. · 0 citations

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