An in vitro system that generates inducible yolk sac myeloid progenitors (iYSMPs) to model human myeloid ontogeny and define a human yolk sac progenitor state with broad TRM differentiation potential, opening avenues for investigating human myeloid ontogeny and developing macrophage cell replacement therapies to treat...
Anna Martinez-Muriana, Nicola Fattorelli, L. Wolfs et al.· Developmental Cell· 0 citations
Tau pathology closely tracks neuronal loss in Alzheimer's disease, but how phosphorylated tau becomes lethal has remained unclear. Chen et al. identify a dual-hit mechanism: glucose hypometabolism removes a protective A20-mediated brake on necroptosis while phosphorylated tau scaffolds RIPK1 activation, driving tau-ass...
A chimeric model of AD is generated by transplanting isogenic APOE3 or APOE4 human induced pluripotent stem cell-derived astrocyte progenitors into neonatal AD mice and highlighting a role for human astrocytes and APOE-dependent astrocyte functions in modulating AD-related pathology.
Joan Cruz-Sesé, Marta Mirón-Alcala, Maria Alfonso-Triguero et al.· Cell Reports· 0 citations
It is found that astrocytic cytosolic calcium activity is suppressed prior to amyloid plaque deposition and is accompanied by reduced lysosomal acidification in vivo, identifying lysosomal failure as an initiating event in astrocyte dysfunction in AD.
D. Shah, P. Desai, C. Chertavian et al.· bioRxiv· 0 citations
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