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Author

B. Cheknane

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Open access Aug 2026

FORMULATION, OPTIMIZATION AND IN VITRO EVALUATION OF A CELLULOSE DERIVATIVE-BASED MATRIX SYSTEM FOR EXTENDED-RELEASE METFORMIN USING RESPONSE SURFACE METHODOLOGY

This study aimed to develop and optimize an extended-release (ER) metformin hydrochloride matrix tablet using hypromellose as the matrix-forming polymer. ER formulations of metformin are crucial as they provide stable plasma concentrations, reduce dosing frequency and gastrointestinal side effects, enhancing patient ad...

Anis Amtsif, F. Zermane, B. Cheknane et al. · 0 citations

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