Author

B. Bitler

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Open access Aug 2026

Inhibiting CXCR2 Remodels the Tumor Microenvironment and Blunts Tumor Progression and Dissemination of High-Grade Serous Carcinoma

Abstract High-grade serous carcinoma (HGSC) of the ovary, fallopian tube, and peritoneum has an immunosuppressive tumor immune microenvironment (TIME), mediated in part by infiltrating innate immune cells such as macrophages, neutrophils, and myeloid-derived suppressor cells (MDSC). We hypothesize that manipulating the...

Railey G Mikeska, L. E. Feldman, Elizabeth R. Woodruff et al. · Cancer Research Communicatio... · 0 citations

Open access Sep 2026

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

This study reveals a previously unrecognized mechanism linking metabolism to epigenetic regulation through platinum-induced remodeling and establishes the MAT2A-SAM axis as a promising therapeutic target to enhance platinum sensitivity by abrogating DNA damage response and OCSC enrichment and ultimately reduce OCSC-dri...

Shu Zhang, Zhen Fu, Yan-Chi Zhou et al. · bioRxiv · 0 citations

Jul 2026

Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.

Poly(ADP-ribose) polymerase inhibitors (PARPi) are a first-line treatment for epithelial ovarian cancer (EOC) patients, but the development of resistance limits long-term therapeutic efficacy. Tumor acidosis is a hallmark of the tumor microenvironment that has been shown to promote resistance to cancer therapies, sugge...

Kaixin Cheng, Hao Nie, Wei Zhou et al. · Cancer Research · 0 citations