Author

B. Baune

3 papers indexed here

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Open access Aug 2026

Comparing trajectories of cognitive functioning in treatment-resistant and non-resistant depression: a multicentre linear mixed-effects analysis.

BACKGROUND Impaired cognitive functioning is a severe symptom in major depressive disorder (MDD). Recent evidence suggests it may be a central characteristic in its treatment resistant form (TRD), potentially constituting a clinical marker for treatment resistance and a target amenable to intervention. To date, cogniti...

V. T. Wahner, T. Lange, Inga Stonner et al. · Journal of Affective Disorde... · 0 citations

Open access Sep 2026

708. From molecules to meaning: metabolomic and transcriptomic pathways to overcoming treatment resistance

Abstract Background Treatment resistance remains a major barrier to improving outcomes in severe psychiatric disorders, reflecting substantial biological heterogeneity that is not captured by symptom-based diagnosis alone. Emerging multi-omics approaches—particularly metabolomic profiling combined with transcriptome-in...

B. Baune · International Journal of Neu... · 0 citations

Review Open access Sep 2026

Pharmaco-multiomics in major depressive disorder: a narrative review and proposed translational framework for difficult-to-treat and treatment-resistant depression

Background Antidepressant prescribing in major depressive disorder (MDD) remains dominated by sequential trial and error, particularly when illness becomes difficult to treat (DTD) or meets conventional treatment-resistant depression (TRD) criteria. Objective This narrative review evaluates pharmacogenomics (PGx), ther...

B. Baune · Frontiers in Pharmacology · 0 citations