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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

B. Al-Lazikani

h-index 41 View on Semantic Scholar

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Review Sep 2026

The evolving landscape of drug targets.

This Review map and quantify key elements of changes in the number and type of targets through which drugs mediate their therapeutic effects, which now include 686 biomolecules modulated by 1,702 drugs.

L. Halip, Sorin Avram, John P. Overington et al. · 0 citations
Aug 2026

Sulfonyl-Imidazopyridines Decouple Reactivity from Stability for Ligandability Mapping and Covalent Inhibitor Discovery

Covalent probes and therapeutics must balance electrophilicity and stability for function in biological systems, yet gains in stability can sacrifice proteome coverage and limit ligand discovery. Here, we show that single-atom N-to-C substitutions of sulfonyl purines at the nucleofuge position decouple reactivity fro...

Zhihong Li, Madeleine L. Ware, Phillip W. Gingrich et al. · 0 citations

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