Author

B. Afzali

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Open access Oct 2026

Intracellular complement Factor B couples inflammatory sensing to metabolism, chromatin regulation and maladaptive tissue repair

Inflammatory signals are broadly conserved, yet how tissue context converts them into programs of recovery or maladaptive repair remains unclear. Using kidney injury as a model of inflammation-to-repair transitions, we identify an injury-induced proximal-tubule complement program in which cell-intrinsic complement prot...

Tilo Freiwald, Daniel Chauss, Md Tajmul et al. · bioRxiv · 0 citations

Open access Aug 2026

Natural microbiota confer life-long protection against obesity via an early-life, immune-mediated effect on brown adipocytes

Abstract Obesity, a major risk factor for metabolic disease, has increased in industrialized nations alongside a reduction in gut microbiota diversity. Reconstituting laboratory mice with complex, natural microbiota and commensals from wild mice resulted in protection against diet-induced obesity. These natural microbi...

Shahar Azar, Oksana Gavrilova, Greta Baker et al. · Gut microbes · 0 citations

Open access Jul 2026

A distal transcribed enhancer of KRAS fine-tunes Tfh-mediated vaccine response 2308711

A systematic catalog of eRNAs in human adaptive immune cells is defined and a distal transcribed enhancer is identified that fine-tunes KRAS signaling in Tfh cells to support effective vaccine responses, establishing eRNAs as noncoding regulators of T cell circuits controlling antibody production.

Dhaneshwar Kumar, S. Sahoo, B. Yan et al. · Journal of Immunology · 0 citations