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Azim Dehghani Amirabad

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#artificial intelligence Preprint Oct 2026

VCLMU: Mechanism-Centric Virtual Cell World Modeling for Perturbation Response

A mechanism-centric virtual cell world model that represents cellular state as a set of Latent Mechanism Units (LMUs) and treats genetic perturbations as actions on these latent states supports mechanism-level latent state transition as a useful formulation for virtual cell models that aim to predict and interpret cell...

Yu-Wei Miao, Azim Dehghani Amirabad, S. Oloff et al. · 0 citations
Preprint Aug 2026

PaSTel: Anchoring Histology in Spatial Transcriptomics via Multi-Scale Hierarchical Bio-Prior Contrastive Pretraining

PaSTel is introduced, a hierarchical multimodal pretraining framework that integrates biological priors at three levels that consistently outperforms existing vision and vision-omics encoders, demonstrating that incorporating multiscale biological priors yields more informative and transferable representations for spat...

Azim Dehghani Amirabad, Jun-Chao Zhu, Pushpak Pati et al. · 0 citations

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