Azariyas A. Challa

Skeletal Muscle Dysfunction in Heart Failure: Mechanistic Insights and Therapeutic Implications.

Exercise intolerance is a hallmark of heart failure (HF) and a strong predictor of morbidity and mortality. Accumulating evidence suggests that alterations in skeletal muscle (SkM) structure and metabolism are key contributors to exercise intolerance in patients with HF. These alterations include reduced muscle mass, i...