Ayon Pal

Comparative phylogenomics of bacterial urease systems reveals architectural conservation, lineage-specific specialization, and candidate horizontal transfer

Age-Opposed Rewiring of Upstream Translation-Initiation Pattern Across Different Types of Human Cancers.

The 5' mRNA leader regulates translation through its length and upstream open reading frames (uORFs), but its systematic remodeling in cancer remains unclear. We analyzed isoform-weighted 5' leader features across The Cancer Genome Atlas, the Genotype-Tissue Expression transcriptomes and the Clinical Proteomic Tumor An...

Exploration of binding mechanism of two potential natural alkaloids as AgrA inhibitors of quorum sensing: molecular docking, molecular dynamics simulation, ADMET and DFT analysis

Currently, targeting bacterial QS is one of the best ways to resolve the problem of bacterial resistance. In agr QS system, the LytTR domain of AgrA regulates the expression of various virulence genes. So, agr QS mediated virulence factors secretion and biofilm formation can be prevented by blocking the DNA binding Lyt...