Spatial transcriptomics identifies L6 corticothalamic and L6b subplate-like heterotopic neurons in an epileptogenic SLC35A2-associated brain malformation
Using imaging-based spatial transcriptomics of SLC35A2-mutated MOGHE tissues, it is found that most WM heterotopic neurons exhibited molecular signatures of excitatory neurons, and a new perspective on disease pathophysiology centered on deep-layer excitatory neuronal populations is suggested.