Formulation and Physicochemical Characterization of Paliperidone- Loaded Niosomal Vesicles for Improved Transdermal Drug Delivery.
INTRODUCTION/OBJECTIVE Niosomes are nonionic surfactant-based vesicular systems. Paliperidone, which is an atypical antipsychotic used in the management of schizophrenia, exhibits poor aqueous solubility and limited oral bioavailability, which could limit its therapeutic effectiveness. This study aimed to develop and o...