Author

Aya Megahed

2 papers indexed here

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Oct 2026

Hesperidin attenuates methotrexate-induced cardiotoxicity: Modulation of Nrf2 antioxidant defense and NF-κB/iNOS proinflammatory signaling.

Methotrexate (MTX) is a commonly used chemotherapeutic and immunosuppressive agent, although serious adverse effects, including cardiotoxicity, sometimes compromise its clinical use and effectiveness. This work was designed to investigate the mechanisms underlying MTX-induced cardiac injury and to evaluate the potentia...

M. Eldesoqui, E. Albadawi, O. Erfan et al. · Tissue & Cell · 0 citations

Open access Sep 2026

Silymarin and Zinc Oxide Nanoparticles Attenuate Experimental Colon Cancer in Rats Through Crosstalk of miR-192 and β-Catenin Pathways

Colon cancer (CC) is a leading cause of cancer-related mortality globally. Although chemotherapy remains the primary treatment, its toxicity and drug resistance highlight the need for alternative therapeutic strategies. Silymarin (Sily), a natural compound, and zinc oxide nanoparticles (ZnO-NPs) have shown potential an...

Eman H. Yousef, Aya Megahed, A. Samy et al. · Biomolecules · 0 citations