Open access
Aug 2026
Human brain organoids record the passage of time over multiple years
It is shown that in chimeric organoids generated by mixing neural progenitors of different ages, old progenitors rapidly produce late neuronal fates, skipping the production of earlier neuronal progeny, therefore showing that progenitors that age in organoids retain a memory of the time spent in vitro.
Irene Faravelli, Noelia Antón-Bolaños, An-Qi Wei et al.
· Nature · 6 citations