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This chapter outlines a comprehensive protocol for joint embedding of chromatin accessibility and transcriptomic data using best practices developed in laboratories, along with detailed parameter tuning at each step to fully leveraging this pipeline.
A comprehensive RNA-sequencing analysis of postmortem nucleus accumbens tissue from individuals with OUD and matched controls provides an integrated view of candidate genetic and transcriptomic alterations in OUD and identifies lncRNA-centered regulatory networks and candidate variant-bearing genes as hypothesis-genera...
It is proposed that the upregulated lncRNA ENSG00000265613 may enhance malignancy by stabilizing the RNA target ENSG00000582008 in luminal A breast cancer, particularly given its established role in oncogenesis.
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