Multi-omics characterization of 2 patients with biallelic HYOU1 variants reveals that HYOU1 deficiency impairs the unfolded protein response, disrupts early B cell development, and alters neutrophil granulation as well as IFN signalling, further establishing ER proteostasis as a contributor to human immune homeostasis.
Aida Idani, S. Bibi-Triki, Tristan Stemmelen et al.· Journal of human immunity· 0 citations
Orthobunyaviruses are linked to a broad spectrum of neurological disorders. However, the molecular determinants governing bunyavirus neuropathogenesis remain poorly understood, precluding the identification of drugs able to alleviate virus-induced neuronal dysfunctions. Here, we show that the prevalent, yet neglected,...
Barbara Gorda, Jules Bouget, Vaishali Saini et al.· Nature Communications· 0 citations
The growth phase-dependent transcriptomic rearrangements under biodesulfurization conditions appear to prioritize cellular homeostasis and protection rather than proliferation, and the strongest transcriptomic response was evident during the late-log phase.
Ashraf M. El Nayal, V. Sangal, A. Alioua et al.· Applied and Environmental Mi...· 0 citations
A sample-aware diaPASEF method optimization strategy for a timsTOF platform that demonstrates the most substantial impact on low-abundance proteins and provides an opportunity for a more precise and comprehensive analysis of the biological functions of biomarkers.
J. Rijal, Imane Charmarke Askar, Aurélie Hirschler et al.· Analytical Chemistry· 0 citations
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