Spermatogonial stem cells (SSCs) sustain spermatogenesis throughout life by generating differentiating spermatogonia, spermatocytes, and spermatozoa. During this process, male germ cells are interconnected by intercellular bridges (ICBs). Although ICB fragmentation has been implicated in the replenishment of the SSC po...
Yusuke Sakurai, Hozumi Nomura, Kazumasa Aoyama et al.· Molecular Reproduction and D...· 0 citations
Rapid development of host immunity is critical during the emergence of viral outbreaks when vaccines are not yet available. Here, we demonstrate that CpG oligodeoxynucleotide-schizophyllan complex (K3-SPG) induces antigen-independent, long-term protection against lethal respiratory virus infection. A single intranasal...
Asuka Joy Tobuse, K. Kobiyama, Jun Tsuchida et al.· Science Advances· 0 citations
In insight into HSC aging, Pbx1 is identified as a key regulator of these age-related transcriptional and differentiation changes and may inform approaches to modulate age-associated HSC dysfunction.