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Atsushi Iwama

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Open access Sep 2026

JMJD3 Deficiency Alters H3K27me3 Landscapes and Adhesion‐Related Transcriptional Programs in Aged Spermatogonia

Spermatogonial stem cells (SSCs) sustain spermatogenesis throughout life by generating differentiating spermatogonia, spermatocytes, and spermatozoa. During this process, male germ cells are interconnected by intercellular bridges (ICBs). Although ICB fragmentation has been implicated in the replenishment of the SSC po...

Yusuke Sakurai, Hozumi Nomura, Kazumasa Aoyama et al. · 0 citations
Open access Oct 2026

Long-term immunoprophylaxis by TLR9 ligand mediates macrophage-ILC cross-talk against respiratory viral infection

Rapid development of host immunity is critical during the emergence of viral outbreaks when vaccines are not yet available. Here, we demonstrate that CpG oligodeoxynucleotide-schizophyllan complex (K3-SPG) induces antigen-independent, long-term protection against lethal respiratory virus infection. A single intranasal...

Asuka Joy Tobuse, K. Kobiyama, Jun Tsuchida et al. · 0 citations

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