Athira M. Sarath

Expression of mutant Huntingtin induces proteasomal defects, mitochondrial abnormalities, and cell death in Drosophila muscles.

Huntington's disease is an inherited neurodegenerative disorder characterized by the progressive loss of neurons, particularly in the basal ganglia, resulting from a mutation in the Huntingtin gene. Recently, skeletal muscle defects have emerged as a contributing factor in HD pathogenesis. However, the mechanistic role...