Open access
Oct 2026
Structural dynamics of substrate processing by the p97-Ufd1-Npl4-FAF1 machinery
The AAA-ATPase VCP/p97 unfolds ubiquitylated proteins in key signaling and cellular homeostasis pathways, yet the mechanisms by which Ufd1-Npl4 and FAF1 adapters handle ubiquitin chains to coordinate substrate loading and processing remain unclear. Our cryo-EM study of p97-Ufd1-Npl4 and FAF1 engaging a substrate reveal...
Athina Drakonaki, J. van den Boom, Alexander Kröning et al.
· Nature Communications · 0 citations