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Author

Aswathi Jyothkumar

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2 papers indexed here

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Open access Sep 2026

Synthesis, In Silico and In Vitro Evaluation of Cholinesterase and Tyrosinase Inhibition of Benzothiazinones for Cognitive Disorders

Objective: Cognitive disorders, including Alzheimer’s disease (AD) are multifactorial conditions associated with cholinergic dysfunction and oxidative stress linked to abnormal melanogenesis. This study aimed to design, synthesise, and evaluate novel benzothiazinone derivatives for their dual inhibitory activity agains...

Sindhu T. J., J. James, Z. C. et al. · 0 citations
Sep 2026

Computational Design and Virtual Screening of Enumeration-Generated Benzothiazinone Derivatives as Cholinesterase Inhibitors Using Pharmacophore Modelling, Molecular Dynamics, DFT and ML-Based Predictive Modelling Analysis

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are key cholinergic targets implicated in Alzheimer’s disease (AD), and simultaneous modulation of these enzymes represents a promising strategy for addressing cholinergic dysfunction. In the present study, a comprehensive computational approach was employed...

T. Abhijith, J. James, T. Sindhu et al. · 0 citations

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