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Author

Asmaa M. Yousif

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Open access Jul 2026

Decoding Histone-DNA Methylation Crosstalk in Exhausted T Cells to Enhance Immunotherapy 2253691

A central histone—DNA methylation circuit, regulated by KDM5A/B and DNMT3A, that drives epigenetic scarring and terminal exhaustion in CD8 T cells is uncovered and Therapeutic targeting of this circuit offers a novel approach to epigenetically reprogram TEX cells and enhance the efficacy of cancer immunotherapy.

Hazem E. Ghoneim, Amira Yousif, Abbey A. Saadey et al. · 0 citations
Jul 2026

A novel microbial-derived metabolite counteracts exhaustion programming in CD8 T cells 2260531

These findings identify a novel microbial SCFA as a potential metabolic-epigenetic regulator, capable of reactivating effector programs in TEX cells while blocking terminal exhaustion, and provide insights into developing new therapeutic approaches to reprogram TEX cells and enhance the efficacy of T cell immunotherapy...

Asmaa M. Yousif, Amira Yousif, Ava Lowin et al. · 0 citations

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