Author

Ashwin K. Jainarayanan

2 papers indexed here

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Review Open access Sep 2026

Pathological neural and immune synapses in glioblastoma progression: mechanisms and therapeutic opportunities

Glioblastoma (GBM), a high-grade glioma, is the most common primary brain tumor in adults, with a dismal prognosis and a very high recurrence rate. Major challenges to effective treatment arise from the tumor’s locally aggressive, diffusely infiltrative nature and extensive intratumoral heterogeneity. Recent advances i...

Ashwin K. Jainarayanan, Aishwarya Vedula, Neeraj Soni · Frontiers in Neural Circuits · 0 citations

Open access Aug 2026

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease

The primary mechanism and subcellular localisation of α-synuclein toxicity in Parkinson’s disease pathogenesis remain unknown. We spatially and temporally resolved proteomic and transcriptomic changes in human iPSC-derived dopaminergic neurons with increasing burden of pathological α-synuclein. We found that misfolded...

Chor Lai Lam, N. Gatford, Ana Aragón-González et al. · Nature Communications · 0 citations