Author

Ashlesha Gogate

2 papers indexed here

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Aug 2026

Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling.

A non-random nuclear "ribome," the genome-wide landscape of embedded rNMPs, enriched in GC-rich regions, regulatory elements, and telomeres, is revealed, revealing a connection between ribonucleotide processing and transcription-associated DNA topology in human cells.

Deepali L. Kundnani, Yeunsook Lee, Taehwan Yang et al. · Cell · 0 citations

Open access Sep 2026

Systematic CRISPRi perturbation of 1,408 autism risk genes maps multilevel transcriptional convergence in human cortical neurons

A CRISPRi Perturb-seq screen targeting 1,408 ASD risk genes in human embryonic stem cell-derived immature cortical neurons is performed and the resulting transcriptomic effects by single-cell RNA sequencing are profile by single-cell RNA sequencing.

Ashlesha Gogate, Wei-Chen Chen, Mpathi Nzima et al. · bioRxiv · 0 citations