Decoding Extrahepatic Targeting of Lipid Nanoparticles with Interpretable Machine Learning
An interpretable machine learning framework is developed to predict hepatic versus extrahepatic LNP accumulation and identify molecular design rules for extrahepatic RNA delivery and provides actionable design principles for engineering LNPs beyond the liver.
Asal Mehradfar, M. Sepehri, Owen Antholine et al.
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