Open access
Sep 2026
Tissue- and compartment-resolved brain age reveals vascular-metabolic and neurodegenerative aging
Abstract Brain aging reflects heterogeneous vascular-metabolic and neurodegenerative processes, yet brain age is often reduced to a gray matter (GM)-dominant estimate. Emerging evidence suggests that subtle “dirty-appearing” T2-FLAIR abnormalities may mark diffuse white matter (WM) vulnerability that precedes or extend...
Hosung Kim, Cong Zang, Jin-Soo Lee et al.
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