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Author

Arpita Mukherjee

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Review Open access Sep 2026

Decoding immunotherapy resistance in glioblastoma: mechanistic limitations, clinical trial failures, and strategic roadmaps for next-generation checkpoint modulation

Glioblastoma (GBM) remains one of the most treatment-refractory malignancies, characterized by profound intratumoral heterogeneity, an immunologically “cold” microenvironment, and rapid adaptive resistance to immune checkpoint inhibition. Despite mechanistic advances targeting PD-1, PD-L1, and CTLA-4 pathways, clinic...

Arpita Mukherjee · 0 citations
Review Aug 2026

Cytokine circuitries as determinants of response, resistance, and toxicity across cancer immunotherapy platforms.

The available evidence supports a transition from static cytokine measurements toward dynamic cytokine network analysis while underscoring the scientific and clinical challenges that must be addressed before cytokine circuitry-informed strategies can be implemented in precision immuno-oncology.

Arpita Mukherjee · 0 citations
Review Open access Jul 2026

Analytical dissection of CRISPR-Cas9-mediated gene editing fidelity: integrating next-generation bioanalytical platforms for precision immunotherapeutics and rare disease correction

This review focuses on analytical and translational frameworks for CRISPR fidelity assessment, with emphasis on the strengths and limitations of current bioanalytical platforms.

Arpita Mukherjee · 1 citation

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