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Author

Arjun Rijal

2 papers indexed here

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Open access Oct 2026

HSF1 inhibition potentiates the antifungal activity and proteome instability induced by the fungal Hsp110 inhibitor 2H

Fungal infections remain a major cause of morbidity and mortality worldwide; however, therapeutic options are limited and are increasingly compromised by antifungal resistance. Heat Shock Protein 110 kDa (Hsp110) is an essential molecular chaperone required for protein homeostasis (proteostasis) and fungal viability an...

Can-Can Sun, Balaji Nagarajan, Arjun Rijal et al. · 0 citations
Open access Oct 2026

Hepatocyte Serine Palmitoyltransferase 3 is essential for mitochondrial ceramide homeostasis and electron transport chain function.

Sphingolipids constitute essential membrane lipids that also function as signaling molecules mediating fundamental cellular processes. Disruption of constitutive sphingolipid metabolism contributes to a range of metabolic diseases. Sphingolipid biosynthesis is initiated by serine palmitoyltransferase (SPT), a heteromer...

Maryam Jamil, Anna Kovilakath, Yolander A. Valentine et al. · 0 citations

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