Author

Arjun Raj

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Open access Sep 2026

Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent gene expression in gastruloids

Gastruloids are stem-cell-based models that recapitulate key aspects of mammalian gastrulation, including the formation of an anterior-posterior axis. However, we do not have detailed spatial information about gene expression and cell type organization, particularly at the level of individual gastruloids. Here, we repo...

Catherine G. Triandafillou, P. Sompalle, Yael Heyman et al. · eLife · 0 citations

Open access Oct 2026

Single-cell spatial transcriptomics of inherited retinal degeneration reveals broad and focal organization of disease responses

Inherited retinal degenerations are largely monogenic disorders characterized by progressive photoreceptor dysfunction and death. Although the transcriptomic responses to inherited degeneration are well-characterized, how these responses are spatially organized across the retinal axis has not been mapped. Here, we used...

Aya A. Abu-Alfa, Ryan Passino, Zhang-Yong Wei et al. · bioRxiv · 0 citations