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Ariana E. Nelson

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#protein folding Sep 2026

Abstract B016: Novel mutations in nicotinamide phosphoribosyltransferase (NAMPT) arising from OT-82 exposure drive resistance in rhabdomyosarcoma (RMS) models

Abstract Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma, and new treatments are urgently needed. Our prior work showed RMS has enhanced sensitivity to pharmacological inhibitors of NAMPT, the rate-limiting enzyme of the NAD+ salvage pathway and the only clinically targetable enzyme of NAD+ synt...

Ariana E. Nelson, Abantika Chakraborty, David R. Bell et al. · 0 citations

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