Author

Aram F. Hezel

2 papers indexed here

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Sep 2026

Abstract B143: Functional screening of Arid1a-deficient pancreatic adenocarcinoma using the MAPS platform

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with limited therapeutic options. Approximately one-third of PDAC tumors harbor alterations in chromatin-remodeling genes, including loss-of-function mutations in ARID1A occurring in approximately 8% of cases. However, actionable vulnerabilities...

Wen-Jia Wang, Olivia Schmidt, S. Blick-Nitko et al. · Cancer Research · 0 citations

Open access Aug 2026

UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis

Metastatic dissemination is the principal cause of death in pancreatic ductal adenocarcinoma (PDAC), yet the molecular determinants that enable this process remain poorly understood. Here, we identify the axon guidance receptor UNC5B as a central regulator of PDAC metastasis. Using both genetically engineered KPCU and...

Muhammad Sadeqi Nezhad, Chris R. Harris, O. Prela et al. · Oncogene · 0 citations