Author

Anwar Alam

2 papers indexed here

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Open access Sep 2026

Prime Editing Corrects the HBB Codon 8/9 (+G) Mutation in Patient-Derived Induced Pluripotent Stem Cells and Restores β-Globin Expression in iPSC-Derived Erythroid Cells

Background Homozygosity for the HBB codon 8/9 (+G) frameshift (c.27dup (p.Ser10ValfsTer14)) causes transfusion-dependent β⁰-thalassaemia and is common in South Asia. Prime editing can reverse this insertion without double-strand breaks or donor DNA, but its efficiency depends on pegRNA design. Methods We derived Sendai...

Irfan Hussain, Kainaat Mumtaz, Maliha Javed et al. · bioRxiv · 0 citations

Open access Sep 2026

In silico assessment of natural compounds against mycobacterium tuberculosis Rv1509 protein

Tuberculosis (TB) remains a leading cause of mortality globally, driven by the infectious pathogen, Mycobacterium tuberculosis (M.tb). A novel DNA methyltransferase (DNA MTase), encoded by the Rv1509 gene and involved in TB pathogenesis, has been identified as a promising therapeutic target of anti-TB drugs. The presen...

Haleema Fayaz, Waseem Ali, Gauri Shrivastava et al. · Applied Biological Chemistry · 0 citations