Sigma-1 receptor involvement in the paradigm-dependent anti-amnesic effects of multimodal HBK-10 under NMDA receptor hypofunction, with accompanying hippocampal ERK1/2 and BDNF modulation.
Findings indicate that HBK-10 combines sigma-1 receptor engagement with paradigm-dependent anti-amnesic efficacy and post-behavioral changes in hippocampal plasticity-related markers, supporting its further pharmacokinetic and mechanistic characterization as a multimodal compound with potential relevance for cognitive...