Most Triple Negative Breast Cancers (TNBCs) are p53 mutant high-grade invasive ductal carcinomas with a basal-like transcriptional programme. A large proportion of TNBCs also have mutation signatures indicating defective homologous recombination (HR) DNA repair. While HR deficiency is mutagenic and oncogenic, it can al...
V. Amodeo, D. Weekes, Nicolae Balan et al.· Nature Communications· 0 citations
DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segregation in favor of alternative pathways that depend on TOPBP1 and CIP2A, but how these pathways function is still poorly...
Kaima Tsukada, L. Lototska, A. Tsukada et al.· Cell· 2 citations
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates, as well as mitotic DNA intertwinements, yet how its diverse activities are regulated remains unclear. Here, we identify key determinants of stable assembly of the BTRR complex on ultrafine DNA bridges (UFBs). We reveal that...
U. Aliyaskarova, Özgün Özer, Mahafuzul Sumon et al.· bioRxiv· 0 citations
Structural and ligand-binding features of HRI are defined to support ongoing drug discovery efforts in blood cancer to support ongoing drug discovery efforts in blood cancer.
M. Rajasekaran, Jessica Booth, Damien Crepin et al.· bioRxiv· 1 citation
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