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Antonio Grimaldi

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Open access Sep 2026

How conformational dynamics shape hydrogen-deuterium exchange isotopic envelopes.

Hydrogen-deuterium exchange mass spectrometry (HDX-MS) measures peptide-level mass distributions, whereas exchange is controlled microscopically by fluctuations in the exposure of individual backbone amides. In this work, exchange is represented in terms of integrated conformation-dependent instantaneous exchange rates...

Antonio Grimaldi, Emanuele Paci · 0 citations

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