Antonietta Ferretti

Inherited platelet function disorders: a comprehensive narrative review focusing on diagnostic and management aspects

Qualitative and quantitative inherited platelet disorders (IPDs) are a heterogeneous group of rare bleeding conditions caused by inherited variants in genes that affect platelet production and function. Clinically, IPDs are characterized by significant phenotypic heterogeneity, ranging from mild mucocutaneous bleeding...

cen-The expanded universe of thrombin: a comprehensive review of its hemostasis-independent roles and structure-function relationships

The expanded universe of thrombin: a comprehensive review of its hemostasis-independent roles and structure-function relationships

The molecular basis of thrombin’s versatility is explored, focusing on its allosteric regulation by sodium ions, its two anion-binding exosites, and its primary signaling mechanism via protease-activated receptors.