Author

Anran Zhang

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Open access Aug 2026

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

It is demonstrated that CMA activity is downregulated in nucleus pulposus cells from IDD patients and IL‐1β‐induced rat intervertebral disc cell models, causing cytoplasmic accumulation of a novel CMA substrate, Midnolin (MIDN).

Xianglong Chen, Hai-Yang Gao, Wang Wu et al. · Advancement of science · 0 citations