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Anne-Lise Paupiah

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Open access Sep 2026

Epileptic encephalopathy-related Kv2.1 mutants impair clustering but not neuronal excitability.

The voltage-gated potassium channel Kv2.1, encoded by the epileptic encephalopathy-associated gene KCNB1, is a primary driver of delayed-rectifier K+ currents in neurons. These currents contribute to high-frequency firing by preventing depolarization block due to Na+ channel inactivation. Wild-type (WT) channels are lo...

Anne-Lise Paupiah, Melvyn Ginisty, Capucine Gendre et al. · 0 citations

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