Author

Annabelle Ryu

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Open access Sep 2026

Host membrane cholesterol constrains constitutive signaling of the oncogenic KSHV GPCR ORF74

Cholesterol is a major structural component of the plasma membrane and a key allosteric regulator of G protein-coupled receptors (GPCRs), yet its role in controlling constitutive receptor activity remains poorly understood. Virally encoded GPCRs provide an ideal system to address this question because many exhibit cons...

J. Park, A. Sahoo, Annabelle Ryu et al. · bioRxiv · 0 citations

Open access Sep 2026

Foldamers With Two Distinct Helical Motifs Controlled by Solvent.

Abiotic foldamers that switch between distinct, well-defined geometries are rare. Here, we report a structurally simple series of oligomers with alternating ortho-phenylene and 2,3-pyrazinylene repeat units. Deconvolution of variable-temperature 1H NMR spectra, with the help of ab initio chemical shift predictions, sho...

Ying Liao, Vipul Batra, G. P. Devkota et al. · Chemistry · 0 citations