Anna S. Thickens

Abstract B116: Myeloid cell co-activation via Dectin-1 and CD40 agonists coordinates non-classical mechanisms of T cell cytotoxicity in Pancreatic Ductal Adenocarcinoma

Immunotherapy efficacy in pancreatic ductal adenocarcinoma (PDA) remains limited due to immune evasion mechanisms like MHCI downregulation which impair T cell–based responses. Strategies engaging alternative cytotoxic pathways are needed to overcome such resistance. We previously demonstrated that coactivation of mye...