Author

Anna M. Díaz-Rovira

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Open access Aug 2026

Proteome-wide identification of the druggable CRBN interactome.

This pipeline identified 6 known and 43 novel CRBN-pomalidomide binders, including orthogonally validated hits that provide privileged starting points for MGD development, and expects this binding-focused workflow to be applicable to other MGD-E3 ligase systems, potentially extending the scope of this emerging drug cla...

Pius Galli, Shuhao Xiao, Y. Meng et al. · Nature Biotechnology · 1 citation

Open access Jul 2026

The Human Bindome: A Proteome-scale Atlas of Designed Binder Candidates

The Human Bindome is presented, a proteome-scale atlas of high-confidence in silico protein binder candidates that positions the Bindome as a resource of genetically encodable perturbagens for site-specific, modular control of protein function.

Julius Wenckstern, Anna M. Díaz-Rovira, Julia A. Kuhn et al. · bioRxiv · 0 citations