Generative AI designs functional thiolation domains for reprogramming non-ribosomal peptide synthetases
Abstract Large language models and generative protein design promise to accelerate biotechnology, but it remains unclear whether they can engineer dynamic megasynth(et)ases whose activity depends on transient, context-specific domain interfaces. Non-ribosomal peptide synthetases (NRPSs) exemplify this challenge and pro...
Emre F. Bülbül, Seounggun Bang, Kevin George et al.
· Nature Communications · 0 citations