Open access
Sep 2026
Conserved C-terminal residues adjacent to the canonical PDX1 homeodomain are required for chromatin occupancy and pancreas development.
Essential roles for the PDX1 transcription factor in pancreatic development and β-cell function are well-known, yet the structure-function relationships of domains within its C-terminus remain incompletely defined. We identified a focal intrinsically disordered region (IDR) spanning residues 207-223 of the Pdx1 C-termi...
Anthony S. Wokasch, Muhammad Shamoon, Courtney Campbell et al.
· Development · 0 citations