Open access
Sep 2026
PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer
Most Triple Negative Breast Cancers (TNBCs) are p53 mutant high-grade invasive ductal carcinomas with a basal-like transcriptional programme. A large proportion of TNBCs also have mutation signatures indicating defective homologous recombination (HR) DNA repair. While HR deficiency is mutagenic and oncogenic, it can al...
V. Amodeo, D. Weekes, Nicolae Balan et al.
· Nature Communications · 0 citations