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Angelique M. Manasseh

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Review Open access Oct 2026

Responsive Neurostimulation of the Centromedian Nucleus of the Thalamus for the Treatment of Drug-Resistant Idiopathic Generalized Epilepsy: A Retrospective Analysis of Efficacy and Exploratory Role of Different Stimulation Frequency Paradigms.

OBJECTIVE Closed-loop (responsive) neurostimulation (RNS) targeting the bilateral centromedian thalamic nucleus (CMN) is a safe and efficacious therapy for idiopathic generalized epilepsy (IGE). However, the optimal stimulation parameters have yet to be elucidated. The aims of this study were to review the efficacy of...

Andrew J. Zillgitt, David E. Burdette, Angelique M. Manasseh et al. · 0 citations

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